Job Description
Job Title: Biochemist/Molecular Biologist Location: Cambridge, MA Type: Contract Compensation: $35-$41.82 Work Model: Onsite – onsite Hours: 40.0 hours/week Overview Our clients BioMedicine Design (BMD) is seeking a highly motivated Biochemist/Molecular Biologist to join Biotherapeutic Expression and Purification group (BEP) in Cambridge, MA. Ideal candidates should have a strong background in molecular biology techniques and experience with nucleic acid production and analysis.
Responsibilities • Independently execute high-throughput plasmid DNA production workflows including bacterial culture, plasmid purification, and downstream sample handling • Operate and troubleshoot automated instrumentation including Biotage, Opentrons, and related liquid handling platforms • Perform DNA quality control testing including gel electrophoresis, nucleic acid quantification, purity assessment, and endotoxin testing • Prepare and submit samples for next-generation sequencing (NGS) and support basic data review of sequencing results • Manage plasmid DNA inventory, sample storage, and tracking within electronic databases and sample management systems • Maintain accurate records in an electronic lab notebook and ensure documentation compliance • Collaborate with expression and purification scientists to ensure timely DNA delivery for downstream workflows • Contribute to process improvements to enhance throughput, reproducibility, and cycle time • Communicate progress, priorities, and risks to meet production schedules and deadlines
Requirements • B.S. in Biological Sciences, Molecular Biology, Biotechnology, Biochemistry, or a related life sciences discipline • 2+ years experience with molecular biology techniques including plasmid preparation, nucleic acid purification, and quantitative DNA analysis • 2+ years experience with bacterial cell culture systems • Proficiency in DNA QC methods including gel electrophoresis and sample preparation for sequencing • Experience operating automated or semi-automated lab instrumentation • Strong organizational skills with the ability to manage multiple projects in a high-throughput setting • Proficiency with electronic lab notebooks and sample tracking systems • Attention to detail during repetitive, high-volume tasks • Strong communication and teamwork skills • Commitment to laboratory safety and compliance
Preferred • Experience with NGS library preparation or sequencing workflows • Familiarity with Python scripting for data analysis or workflow automation • Experience with plate-based (96/384-well) high-throughput workflows • Familiarity with LIMS or sample management platforms (e.g., FreezerPro, Genedata)
System One, and its subsidiaries including Joulé and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.
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